{"id":1076,"date":"2016-08-19T08:36:36","date_gmt":"2016-08-19T13:36:36","guid":{"rendered":"http:\/\/my.dev.vanderbilt.edu\/vinsenews\/?p=1076"},"modified":"2016-08-31T13:55:50","modified_gmt":"2016-08-31T18:55:50","slug":"colloquium-collier","status":"publish","type":"post","link":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/2016\/08\/colloquium-collier\/","title":{"rendered":"VINSE Colloquium Series: &#8220;Supramolecular Materials for Immunomodulation\u201d Dr. Joel Henderson Collier; Duke University 09\/14\/16"},"content":{"rendered":"<pre>Wednesday September 14, 2016\r\n\r\nJoel Henderson Collier\r\nDuke University\r\nAssociate Professor in the Department of Biomedical Engineering\r\n\r\n\u201cSupramolecular Materials for Immunomodulation\u201d<\/pre>\n<p>&nbsp;<\/p>\n<pre>4:10 PM, 134 Featheringill Hall\r\nRefreshments served at 3:45\r\n\r\n<\/pre>\n<p><strong>Abstract:<\/strong><\/p>\n<p>Successful immunotherapies must raise both the correct strength and phenotype of an immune response.\u00a0\u00a0 To treat a particular disease via the immune system, it can be challenging to discover what the optimally protective immune response may be and then reliably achieve it.\u00a0 In part the challenge arises from the fact that the overall phenotype of an immune response includes contributions from many different cell subsets, including T cells, B cells, and antigen presenting cells, all of which interact complexly to generate an integrated response.\u00a0 We have been developing supramolecular materials, primarily comprised of peptides and proteins, which serve as modular platforms for discovering and eliciting clinically important immune responses by engaging and modulating this cellular diversity.\u00a0\u00a0 In this seminar, several different self-assembling components will be described, including synthetic fibrillizing peptides, expressed proteins that can be induced to self-assemble after purification, and ester-containing depsipeptides with tunable hydrolytic properties.\u00a0 This class of materials has surprising self-adjuvanting properties, which we have recently exploited towards several clinical goals.\u00a0 In one example, we are developing novel treatments for chronic inflammation by creating biomaterials that can raise therapeutic levels of TNF-neutralizing antibodies.\u00a0 In this system, the strength and phenotype of the immune response can be modulated and optimized by systematically varying the epitope composition, a task that is greatly facilitated by the materials\u2019 non-covalent construction.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wednesday September 14, 2016 Joel Henderson Collier Duke University Associate Professor in the Department of Biomedical Engineering \u201cSupramolecular Materials for Immunomodulation\u201d &nbsp; 4:10 PM, 134 Featheringill Hall Refreshments served at 3:45 Abstract: Successful immunotherapies must raise both the correct strength and phenotype of an immune response.\u00a0\u00a0 To treat a particular disease via the immune system,&#8230;<\/p>\n","protected":false},"author":4798,"featured_media":1077,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,13],"tags":[23],"class_list":["post-1076","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vinse-colloquium","category-events","tag-vinse-colloquium"],"_links":{"self":[{"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/1076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/users\/4798"}],"replies":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/comments?post=1076"}],"version-history":[{"count":2,"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/1076\/revisions"}],"predecessor-version":[{"id":1094,"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/1076\/revisions\/1094"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/media\/1077"}],"wp:attachment":[{"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/media?parent=1076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/categories?post=1076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/tags?post=1076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}