{"id":903,"date":"2015-12-22T23:00:00","date_gmt":"2015-12-23T04:00:00","guid":{"rendered":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/?guid=239b465122fabe8986fcf0e446818794"},"modified":"2015-12-22T23:00:00","modified_gmt":"2015-12-23T04:00:00","slug":"reply-10","status":"publish","type":"post","link":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2015\/12\/reply-10\/","title":{"rendered":"Reply"},"content":{"rendered":"<p>We reported an effect of proton pump inhibitors (PPIs) leading to vascular dysfunction (Circulation 2013;128:845\u2013853). Based on that finding, we hypothesized that PPIs may be associated with an increased risk of myocardial infarction, and reapplied a validated data-mining method to examine for the presence of a drug safety signal in electronic medical records. With regard to the critique of our paper (PLoS One 2015;10:e0124653), the commentators have attributed many of the limitations of observational studies to our data-mining study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We reported an effect of proton pump inhibitors (PPIs) leading to vascular dysfunction (Circulation 2013;128:845\u2013853). Based on that finding, we hypothesized that PPIs may be associated with an increased risk of myocardial infarction, and reapplied a&#8230; <a href=\"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2015\/12\/reply-10\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":4842,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-903","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/4842"}],"replies":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=903"}],"version-history":[{"count":1,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/903\/revisions"}],"predecessor-version":[{"id":1183,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/903\/revisions\/1183"}],"wp:attachment":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}