{"id":290598,"date":"2021-08-29T08:00:00","date_gmt":"2021-08-29T13:00:00","guid":{"rendered":"http:\/\/my.dev.vanderbilt.edu\/richardpeek\/?guid=6f027461942f2d46565a584a390cf617"},"modified":"2021-08-29T23:00:00","modified_gmt":"2021-08-30T04:00:00","slug":"ptg-100-an-oral-%ce%b14%ce%b27-antagonist-peptide-preclinical-development-and-phase-1-and-2a-studies-in-ulcerative-colitis","status":"publish","type":"post","link":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2021\/08\/ptg-100-an-oral-%ce%b14%ce%b27-antagonist-peptide-preclinical-development-and-phase-1-and-2a-studies-in-ulcerative-colitis\/","title":{"rendered":"PTG-100, an Oral \u03b14\u03b27 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis"},"content":{"rendered":"<p>Oral therapies targeting the integrin \u03b14\u03b27 may offer unique advantages for treatment of inflammatory bowel disease. We characterized the oral \u03b14\u03b27 antagonist peptide PTG-100 in preclinical models, and established safety, pharmacokinetic\/pharmacodynamic relationships and efficacy in a phase 2a trial in ulcerative colitis (UC) patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oral therapies targeting the integrin \u03b14\u03b27 may offer unique advantages for treatment of inflammatory bowel disease. We characterized the oral \u03b14\u03b27 antagonist peptide PTG-100 in preclinical models, and established safety, pharmacokinetic\/pharmacodynamic&#8230; <a href=\"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2021\/08\/ptg-100-an-oral-%ce%b14%ce%b27-antagonist-peptide-preclinical-development-and-phase-1-and-2a-studies-in-ulcerative-colitis\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-290598","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/290598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=290598"}],"version-history":[{"count":25,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/290598\/revisions"}],"predecessor-version":[{"id":291287,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/290598\/revisions\/291287"}],"wp:attachment":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=290598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=290598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=290598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}