{"id":249707,"date":"2021-02-10T02:00:00","date_gmt":"2021-02-10T07:00:00","guid":{"rendered":"http:\/\/my.dev.vanderbilt.edu\/richardpeek\/?guid=41299911dbc0394cb0bff53acac399ce"},"modified":"2021-02-10T23:00:00","modified_gmt":"2021-02-11T04:00:00","slug":"in-esophageal-squamous-cells-from-eosinophilic-esophagitis-patients-th2-cytokines-increase-eotaxin-3-secretion-through-effects-on-intracellular-calcium-and-a-non-gastric-proton-pump","status":"publish","type":"post","link":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2021\/02\/in-esophageal-squamous-cells-from-eosinophilic-esophagitis-patients-th2-cytokines-increase-eotaxin-3-secretion-through-effects-on-intracellular-calcium-and-a-non-gastric-proton-pump\/","title":{"rendered":"In Esophageal Squamous Cells from Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion through Effects on Intracellular Calcium and a Non-Gastric Proton Pump"},"content":{"rendered":"<p>In upper airway cells, Th2 cytokines that signal through IL-4 receptor alpha (IL4R\u03b1) have been shown to stimulate eotaxin-3 secretion via a non-gastric proton pump (ngH+,K+ATPase). To seek novel targets for eosinophilic esophagitis (EoE) treatments, we evaluated ngH+,K+ATPase expression in EoE squamous cells, and explored molecular pathways involved in eotaxin-3 secretion by IL4R\u03b1 signaling.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In upper airway cells, Th2 cytokines that signal through IL-4 receptor alpha (IL4R\u03b1) have been shown to stimulate eotaxin-3 secretion via a non-gastric proton pump (ngH+,K+ATPase). To seek novel targets for eosinophilic esophagitis (EoE) treatments, we&#8230; <a href=\"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2021\/02\/in-esophageal-squamous-cells-from-eosinophilic-esophagitis-patients-th2-cytokines-increase-eotaxin-3-secretion-through-effects-on-intracellular-calcium-and-a-non-gastric-proton-pump\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-249707","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/249707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=249707"}],"version-history":[{"count":25,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/249707\/revisions"}],"predecessor-version":[{"id":251380,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/249707\/revisions\/251380"}],"wp:attachment":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=249707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=249707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=249707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}