{"id":22507,"date":"2017-08-04T11:00:00","date_gmt":"2017-08-04T16:00:00","guid":{"rendered":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/?guid=766a79ac1fd6ad9889ff3161a5a01e6c"},"modified":"2017-08-04T23:00:00","modified_gmt":"2017-08-05T04:00:00","slug":"reply-69","status":"publish","type":"post","link":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2017\/08\/reply-69\/","title":{"rendered":"Reply"},"content":{"rendered":"<p>We thank Dr Yu and colleagues for their letter. We agree that the presence of baseline NS5A resistance-associated substitutions in patients with hepatitis C virus genotype 2 infection reduces the efficacy of ultrashort durations of ledipasvir-sofosbuvir. This is particularly pertinent for patients infected with subtype 2a, where the \u201cwild type\u201d virus seems to harbor NS5A resistance-associated substitutions (10\/11 treatment-na\u00efve patients had either K30R and\/or L31M at baseline).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We thank Dr Yu and colleagues for their letter. We agree that the presence of baseline NS5A resistance-associated substitutions in patients with hepatitis C virus genotype 2 infection reduces the efficacy of ultrashort durations of ledipasvir-sofosbuvi&#8230; <a href=\"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2017\/08\/reply-69\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-22507","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/22507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=22507"}],"version-history":[{"count":24,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/22507\/revisions"}],"predecessor-version":[{"id":23718,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/22507\/revisions\/23718"}],"wp:attachment":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=22507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=22507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=22507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}