{"id":1816,"date":"2016-05-28T17:00:00","date_gmt":"2016-05-28T22:00:00","guid":{"rendered":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/?guid=0a3670b2f53961fb8a2a686155b798f1"},"modified":"2016-05-28T17:00:00","modified_gmt":"2016-05-28T22:00:00","slug":"reply-33","status":"publish","type":"post","link":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2016\/05\/reply-33\/","title":{"rendered":"Reply"},"content":{"rendered":"<p>We thank Macaluso et\u00a0al for their comments about our study on methotrexate in steroid-dependent ulcerative colitis (UC).1 In this trial, parenteral methotrexate was not superior to placebo, using a composite primary endpoint consisting of clinical and endoscopic remission, and complete steroid withdrawal at week 16. However, there were several positive findings in this trial: methotrexate was superior to placebo for inducing clinical remission without steroids at week 16 (a prespecified secondary endpoint) and in a post hoc analysis, a higher rate of treatment discontinuation for UC activity was observed in the placebo arm, than in the methotrexate arm.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We thank Macaluso et\u00a0al for their comments about our study on methotrexate in steroid-dependent ulcerative colitis (UC).1 In this trial, parenteral methotrexate was not superior to placebo, using a composite primary endpoint consisting of clinical and&#8230; <a href=\"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/2016\/05\/reply-33\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5806,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1816","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/1816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5806"}],"replies":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=1816"}],"version-history":[{"count":0,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/1816\/revisions"}],"wp:attachment":[{"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=1816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=1816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=1816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}