Monthly Archives: October 2020
NEW: COVID patient’s heart-lung transplant is world’s first
Vanderbilt University Medical Center has performed the world’s first dual heart-lung transplant of a COVID-19 patient. The complex procedure, completed on Sept. 24, is the first heart-lung transplant VUMC has performed since 2006. Continue reading
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NEW: VUMC to stop N95 mask reprocessing
Thanks to the efforts of all VUMC personnel to conserve and reuse N95 masks, VUMC’s Supply Chain has been able to build up enough supply to cease the N95 sterilization reprocessing program. Continue reading
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Correction
Lee JK, Jensen CD, Levin TR, et al. Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population. Gastroenterology 2020;158:884-894. Continue reading
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Famotidine Use Is Not Associated With 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized COVID-19 Patients from a Large Healthcare System
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Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects
Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer (CRC) risk remain largely unknown. We conducted a transcriptome-wide association study (TWAS) to… Continue reading
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Epigenomic Evaluation of Cholangiocyte TGFβ Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis
Transforming growth factor β (TGFβ) upregulates cholangiocyte-derived signals that activate myofibroblasts and promote fibrosis. Using epigenomic and transcriptomic approaches, we sought to distinguish the epigenetic activation mechanisms downstream of… Continue reading
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“Malignant” liver cysts cause liver failure and recurrence
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A baffling case of recurrent hematochezia
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High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids
Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and susceptibility to… Continue reading
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An unusual case of small bowel obstruction
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