Monthly Archives: February 2018
Microbiota-derived Metabolic Factors Reduce Campylobacteriosis in Mice
Campylobacter jejuni, a prevalent food-borne bacterial pathogen, exploits the host innate response to induce colitis. Little is known about the roles of microbiota in C jejuni-induced intestinal inflammation. We investigated interactions between microb… Continue reading
Prevalence of and Factors Associated with Fecal Incontinence—Results From a Population-based Survey
Fecal incontinence (FI) is characterized by uncontrolled passage of solid or liquid stool. We aimed to determine the prevalence and severity of FI in a large sample of United States residents. Continue reading
Pharmacokinetics and Exposure Response Relationships of Ustekinumab in Patients with Crohn’s Disease
Ustekinumab is a monoclonal antibody that binds with high affinity to the p40 subunit of human interleukin 12 (IL12 and IL23) that has been approved for treatment of patients with moderate to severe Crohn’s disease (CD). However, there are few data o… Continue reading