A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn’s Disease and Reduces Monocyte Signaling via GMCSF

Posted on July 1, 2016 by Ling-Shiang Chuang, Nicole Villaverde, Ken Y. Hui, Arthur Mortha, Adeeb Rahman, Adam P. Levine, Talin Haritunians, Sok Meng Evelyn Ng, Wei Zhang, Nai-Yun Hsu, Jody-Ann Facey, Tramy Luong, Heriberto Fernandez-Hernandez, Dalin Li, Manuel Rivas, Elena R

Crohn’s disease associated frameshift mutation in CSF2RB results in decreased STAT5 activation in a dominant negative manner.

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