Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis

Posted on May 19, 2015 by Matthias Sendler, Georg Beyer, Ujjwal M. Mahajan, Vivian Kauschke, Sandrina Maertin, Claudia Schurmann, Georg Homuth, Uwe Völker, Henry Völzke, Walter Halangk, Thomas Wartmann, Frank-Ulrich Weiss, Peter Hegyi, Markus M. Lerch, Julia Mayerle

Little is known about the pathogenic mechanisms of chronic pancreatitis. We investigated the roles of complement component 5 (C5) in pancreatic fibrogenesis in mice and patients.

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