VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis

Posted on March 21, 2015 by Sebastian Foersch, Tobias Sperka, Christina Lindner, Astrid Taut, Karl L. Rudolph, Georg Breier, Frank Boxberger, Tilman T. Rau, Arndt Hartmann, Michael Stürzl, Nadine Wittkopf, Lisa Haep, Stefan Wirtz, Markus F. Neurath, Maximilian J. Waldner

Senescence prevents cellular transformation. We investigated whether vascular endothelial growth factor (VEGF) signaling via its receptor, VEGFR2, regulates senescence and proliferation of tumor cells in mice with colitis-associated cancer (CAC).

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