Rapamycin Inhibition of mTOR Reduces Levels of the Na+/H+ Exchanger 3 in Intestines of Mice and Humans, Leading to Diarrhea

Posted on March 30, 2015 by Jun Yang, Xiaofeng Zhao, Archana Patel, Rachana Potru, Sadra Azizi-Ghannad, Michael Dolinger, James Cao, Catherine Bartholomew, Joseph Mazurkiewicz, David Conti, David Jones, Yunfei Huang, Xinjun Cindy Zhu

The immunosuppressant rapamycin frequently causes noninfectious diarrhea in organ transplant recipients. We investigated the mechanisms of this process.

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