{"id":1454,"date":"2019-07-23T16:21:48","date_gmt":"2019-07-23T21:21:48","guid":{"rendered":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/?page_id=1454"},"modified":"2019-08-02T10:21:46","modified_gmt":"2019-08-02T15:21:46","slug":"eye-development","status":"publish","type":"page","link":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/home\/2019-projects\/ips-cells-eye\/eye-development\/","title":{"rendered":"Eye Development"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1753 aligncenter\" src=\"https:\/\/cdn-dev.vanderbilt.edu\/t2-my-dev\/wp-content\/uploads\/sites\/2855\/2019\/07\/VEyeDev2-300x250.png\" alt=\"VEyeDev2\" width=\"792\" height=\"660\" srcset=\"https:\/\/cdn-dev.vanderbilt.edu\/t2-my-dev\/wp-content\/uploads\/sites\/2855\/2019\/07\/VEyeDev2-300x250.png 300w, https:\/\/cdn-dev.vanderbilt.edu\/t2-my-dev\/wp-content\/uploads\/sites\/2855\/2019\/07\/VEyeDev2-768x641.png 768w, https:\/\/cdn-dev.vanderbilt.edu\/t2-my-dev\/wp-content\/uploads\/sites\/2855\/2019\/07\/VEyeDev2.png 914w\" sizes=\"auto, (max-width: 792px) 100vw, 792px\" \/><\/p>\n<p style=\"padding-left: 90px\">Fig.1: Basic Dynamics of Vertebrate Eye Development (<a href=\"https:\/\/doi.org\/10.1093\/hmg\/9.6.917\">Wawersik<\/a>)<\/p>\n<p>&nbsp;<\/p>\n<p>Early stages of eye development involve the invagination of E8.5 ectoderm to form the optic cup. (Fig.1A-D) Optic fissure closure occurs during E10.5-E12.5 to generate the continuous presumptive optic structures (Fig.1E-F).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1756 aligncenter\" src=\"https:\/\/cdn-dev.vanderbilt.edu\/t2-my-dev\/wp-content\/uploads\/sites\/2855\/2019\/07\/IMG_20190722_161601734-300x225.jpg\" alt=\"IMG_20190722_161601734\" width=\"563\" height=\"422\" srcset=\"https:\/\/cdn-dev.vanderbilt.edu\/t2-my-dev\/wp-content\/uploads\/sites\/2855\/2019\/07\/IMG_20190722_161601734-300x225.jpg 300w, https:\/\/cdn-dev.vanderbilt.edu\/t2-my-dev\/wp-content\/uploads\/sites\/2855\/2019\/07\/IMG_20190722_161601734-768x576.jpg 768w, https:\/\/cdn-dev.vanderbilt.edu\/t2-my-dev\/wp-content\/uploads\/sites\/2855\/2019\/07\/IMG_20190722_161601734-1024x768.jpg 1024w\" sizes=\"auto, (max-width: 563px) 100vw, 563px\" \/><\/p>\n<p style=\"padding-left: 90px\">Fig.2: VEGF Dependent Vascularization of the Peripheral Retina.<\/p>\n<p>&nbsp;<\/p>\n<p>As the eye develops the peripheral retina becomes hypoxic. Hypoxia induces the release of Vascular endothelial growth factor (VEGF), which induces vascularization of the peripheral retina. (Fig.2)<\/p>\n<p>_________________________________________________________________________________________________________________<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Fig.1: Basic Dynamics of Vertebrate Eye Development (Wawersik) &nbsp; Early stages of eye development involve the invagination of E8.5 ectoderm to form the optic cup. (Fig.1A-D) Optic fissure closure occurs during E10.5-E12.5 to generate the continuous presumptive optic structures (Fig.1E-F). Fig.2: VEGF Dependent Vascularization of the Peripheral Retina. &nbsp; As the eye develops the&#8230;<\/p>\n","protected":false},"author":8394,"featured_media":0,"parent":1380,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-1454","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages\/1454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/users\/8394"}],"replies":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/comments?post=1454"}],"version-history":[{"count":7,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages\/1454\/revisions"}],"predecessor-version":[{"id":2313,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages\/1454\/revisions\/2313"}],"up":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages\/1380"}],"wp:attachment":[{"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/media?parent=1454"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/tags?post=1454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}