{"id":1418,"date":"2019-07-23T11:31:35","date_gmt":"2019-07-23T16:31:35","guid":{"rendered":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/?page_id=1418"},"modified":"2019-08-06T11:15:01","modified_gmt":"2019-08-06T16:15:01","slug":"embryogenesis","status":"publish","type":"page","link":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/home\/2019-projects\/c-elegans-brain\/embryogenesis\/","title":{"rendered":"C. elegans"},"content":{"rendered":"
\"C.
C. elegans<\/em> anatomy. Adapted from: Altun and Hall, 2009<\/a>.<\/figcaption><\/figure>\n

C. elegans\u00a0<\/strong><\/em>as a model organism.\u00a0<\/strong><\/p>\n

Benefits of using C. elegans\u00a0<\/em>as a model organism:<\/p>\n

    \n
  • Short lifecycle<\/strong> :\u00a03 days<\/li>\n
  • Transparent<\/strong>: easy to visualize throughout development<\/li>\n
  • Manageable number of chromosomes<\/strong>:\u00a06 chromosomes<\/li>\n
  • Self propagating hermaphrodites<\/strong>:\u00a0~300 genetically similar progeny does not limit research to sample size<\/li>\n
  • Invariant cell lineage<\/strong>: exactly 959 somatic cells in each adult worm<\/li>\n
  • Germline syncytium<\/strong>: easy to use for transgenics as the cytoplasm is not enclosed until later staged oocytes are produced<\/li>\n
  • Cheap & easy maintenance:\u00a0<\/strong>In lab, C. elegans<\/em> live on agar coated petri dishes which have a layer of E. coli, which C. elegans<\/em> feed on.<\/li>\n<\/ul>\n

     <\/p>\n

    C. elegans\u00a0<\/em>are used in research to study:<\/p>\n

      \n
    • Apoptosis<\/strong>: 131 cells are fated to undergo apoptosis in\u00a0C. elegans<\/em><\/li>\n
    • Gene function<\/strong>: human orthologs in C. elegans<\/em><\/li>\n
    • Congenital heart disease<\/strong>: established model organism to study sarcomeres<\/li>\n
    • Kidney disease<\/strong>: human orthologs\u00a0of kidney-specific genes in C. elegans\u00a0<\/em><\/li>\n
    • Neurological disorders<\/strong>:\u00a0human orthologs\u00a0of neurological-specific genes in C. elegans\u00a0<\/em><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

      C. elegans\u00a0as a model organism.\u00a0 Benefits of using C. elegans\u00a0as a model organism: Short lifecycle :\u00a03 days Transparent: easy to visualize throughout development Manageable number of chromosomes:\u00a06 chromosomes Self propagating hermaphrodites:\u00a0~300 genetically similar progeny does not limit research to sample size Invariant cell lineage: exactly 959 somatic cells in each adult worm Germline syncytium: easy…<\/p>\n","protected":false},"author":8389,"featured_media":0,"parent":1386,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-1418","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages\/1418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/users\/8389"}],"replies":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/comments?post=1418"}],"version-history":[{"count":10,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages\/1418\/revisions"}],"predecessor-version":[{"id":2377,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages\/1418\/revisions\/2377"}],"up":[{"embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/pages\/1386"}],"wp:attachment":[{"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/media?parent=1418"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.dev.vanderbilt.edu\/pdbbootcamp\/wp-json\/wp\/v2\/tags?post=1418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}