Mouse – Kidney

Welcome

Mice are excellent models of human disease and development and are used by many scientists worldwide. According to the Foundation for Biomedical Research, mice and rats make up 95% of all lab animals, with mice being the most commonly used model organism. Like humans, mice are mammals and, therefore, develop inside of the mother. Because of this, mice are the only model organism commonly used to study placental development and processes. Researchers also use the mouse because of its close genetic and physiological similarities to humans, and the ease with which they can manipulate and analyze its genome. Recently, scientists have made use of innovative genetic technologies to create custom-made mouse models in which targeted genes are inserted, deleted, or altered within the mouse genome. These mouse models are utilized to study a variety of different topics, such as cancer, development and aging, immune and blood disorders, neurological and sensory disorders, and metabolic disorders. Mouse models have been extensively used to study kidney development and disease induction and progression, as well as to identify potential therapeutic targets for kidney disease. This website will provide information and resources on how mice have provided insights into human kidney development and disease.