Eye Development

 

Fig.1: Basic Dynamics of Vertebrate Eye Development (Wawersik)

 

Early stages of eye development involve the invagination of E8.5 ectoderm to form the optic cup. (Fig.1A-D) Optic fissure closure occurs during E10.5-E12.5 to generate the continuous presumptive optic structures (Fig.1E-F).

Fig.2: VEGF Dependent Vascularization of the Peripheral Retina.

 

As the eye develops the peripheral retina becomes hypoxic. Hypoxia induces the release of Vascular endothelial growth factor (VEGF), which induces vascularization of the peripheral retina. (Fig.2)

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